Select Page

References – An NR Supplement May Reverse Aging

  1. Johnson S, Imai S. NAD+ biosynthesis, aging, and disease. F1000Res. 2018;7:132.
  2. Cantó C, Menzies KJ, Auwerx J. Nad+ metabolism and the control of energy homeostasis: a balancing act between mitochondria and the nucleus. Cell Metabolism. 2015;22(1):31-53.
  3. Massudi H, Grant R, Braidy N, Guest J, Farnsworth B, Guillemin GJ. Age-associated changes in oxidative stress and nad+ metabolism in human tissue. Polymenis M, ed. PLoS ONE. 2012;7(7):e42357.
  4. Gong B, Pan Y, Vempati P, et al. Nicotinamide riboside restores cognition through an upregulation of proliferator-activated receptor-γ coactivator 1α regulated β-secretase 1 degradation and mitochondrial gene expression in Alzheimer’s mouse models. Neurobiology of Aging. 2013;34(6):1581-1588.
  5. Frederick DW, Loro E, Liu L, et al. Loss of nad homeostasis leads to progressive and reversible degeneration of skeletal muscle. Cell Metabolism. 2016;24(2):269-282.
  6. Imai S, Guarente L. It takes two to tango: NAD+ and sirtuins in aging/longevity control. npj Aging Mech Dis. 2016;2(1):16017.
  7. Trammell SAJ, Schmidt MS, Weidemann BJ, et al. Nicotinamide riboside is uniquely and orally bioavailable in mice and humans. Nat Commun. 2016;7(1):12948.
  8. Lee HJ, Hong Y-S, Jun W, Yang SJ. Nicotinamide riboside ameliorates hepatic metaflammation by modulating nlrp3 inflammasome in a rodent model of type 2 diabetes. Journal of Medicinal Food. 2015;18(11):1207-1213.
  9. Haigis MC, Sinclair DA. Mammalian sirtuins: biological insights and disease relevance. Annu Rev Pathol Mech Dis. 2010;5(1):253-295.
  10. Satoh A, Stein L, Imai S. The role of mammalian sirtuins in the regulation of metabolism, aging, and longevity. In: Yao T-P, Seto E, eds. Histone Deacetylases: The Biology and Clinical Implication. Vol 206. Springer Berlin Heidelberg; 2011:125-162.
  11. Preyat N, Leo O. Sirtuin deacylases: a molecular link between metabolism and immunity. Journal of Leukocyte Biology. 2013;93(5):669-680.
  12. Guarente L. Calorie restriction and sirtuins revisited. Genes & Development. 2013;27(19):2072-2085.
  13. Mendelsohn AR, Larrick JW. The nad+/parp1/sirt1 axis in aging. Rejuvenation Research. 2017;20(3):244-247.
  14. Grube K, Burkle A. Poly(ADP-ribose) polymerase activity in mononuclear leukocytes of 13 mammalian species correlates with species-specific life span. Proceedings of the National Academy of Sciences. 1992;89(24):11759-11763.
  15. Sweeney G, Song J. The association between PGC-1α and Alzheimer’s disease. Anat Cell Biol. 2016;49(1):1.
  16. Bose A, Beal MF. Mitochondrial dysfunction in Parkinson’s disease. J Neurochem. 2016;139:216-231.
  17. Chen X, Stern D, Yan SD. Mitochondrial dysfunction and Alzheimer’s disease. Curr Alzheimer Res. 2006;3(5):515-520.
  18. Maruszak A, Żekanowski C. Mitochondrial dysfunction and Alzheimer’s disease. Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2011;35(2):320-330.
  19. Schöndorf DC, Ivanyuk D, Baden P, et al. The nad+ precursor nicotinamide riboside rescues mitochondrial defects and neuronal loss in ipsc and fly models of parkinson’s disease. Cell Reports. 2018;23(10):2976-2988.
  20. Know your risk for heart disease | cdc. Gov. Centers for Disease Control and Prevention.
  21. Picciotto NE, Gano LB, Johnson LC, et al. Nicotinamide mononucleotide supplementation reverses vascular dysfunction and oxidative stress with aging in mice. Aging Cell. 2016;15(3):522-530.
  22. Martens C, Denman B, Mazzo M, et al. Naa1 nicotinamide riboside supplementation reduces aortic stiffness and blood pressure in middle-aged and older adults: ARTRES. 2017;20(C):49.
  23. Crisol BM, Veiga CB, Lenhare L, et al. Nicotinamide riboside induces a thermogenic response in lean mice. Life Sciences. 2018;211:1-7.
  24. Djouder N. Boosting NAD +for the prevention and treatment of liver cancerMolecular & Cellular Oncology. 2015;2(4):e1001199.
  25. Son MJ, Ryu J-S, Kim JY, et al. Upregulation of mitochondrial NAD+ levels impairs the clonogenicity of SSEA1+ glioblastoma tumor-initiating cells. Exp Mol Med. 2