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References – Propolis that Can Cure Cancer

  1. Machado BA, Silva RP, Barreto Gde A, et al. Chemical Composition and Biological Activity of Extracts Obtained by Supercritical Extraction and Ethanolic Extraction of Brown, Green and Red Propolis Derived from Different Geographic Regions in Brazil. PLoS ONE. 2016;11(1):e0145954.
  2. Freires IA, De alencar SM, Rosalen PL. A pharmacological perspective on the use of Brazilian Red Propolis and its isolated compounds against human diseases. Eur J Med Chem. 2016;110:267-79.
  3. Al-maghrabi J, Emam E, Gomaa W, et al. Overexpression of PAK-1 is an independent predictor of disease recurrence in colorectal carcinoma. Int J Clin Exp Pathol. 2015;8(12):15895-902.
  4. Brems H1, Beert E, de Ravel T, Legius E. Mechanisms in the pathogenesis of malignant tumours in neurofibrosmatosis type 1. Lancet Oncol. 2009 may; 10(5):508-15.
  5. Fang F, Pan J, Li YP, et al. p21-activated kinase 1 (PAK1) expression correlates with prognosis in solid tumors: A systematic review and meta-analysis. Oncotarget. 2016;7(19):27422-9.
  6. Aoki H, Yokoyama T, Fujiwara K, et al. Phosphorylated Pak1 level in the cytoplasm correlates with shorter survival time in patients with glioblastoma. Clin Cancer Res. 2007;13(22 Pt 1):6603-9.
  7. Senapedis W, Crochiere M, Baloglu E, Landesman Y. Therapeutic Potential of Targeting PAK Signaling. Anticancer Agents Med Chem. 2016;16(1):75-88.
  8. Pandolfi A, Stanley RF, Yu Y, et al. PAK1 is a therapeutic target in acute myeloid leukemia and myelodysplastic syndrome. Blood. 2015;126(9):1118-27.
  9. Kumar R, Li DQ. PAKs in Human Cancer Progression: From Inception to Cancer Therapeutic to Future Oncobiology. Adv Cancer Res. 2016;130:137-209.
  10. Patel S. Emerging Adjuvant Therapy for Cancer: Propolis and its Constituents. J Diet Suppl. 2016;13(3):245-68.
  11. Maruta H. Herbal therapeutics that block the oncogenic kinase pak1 a practical approach toward pak 1 dependent disease and logevity. Phytother Res. 2014 May;28(5):656-72.
  12. Nguyen BC, Taira N, Maruta H, Tawata S. Artepillin C and Other Herbal PAK1-blockers: Effects on Hair Cell Proliferation and Related PAK1-dependent Biological Function in Cell Culture. Phytother Res. 2016;30(1):120-7.
  13. Frión-herrera Y, Díaz-garcía A, Ruiz-fuentes J, Rodríguez-sánchez H, Sforcin JM. Brazilian green propolis induced apoptosis in human lung cancer A549 cells through mitochondrial-mediated pathway. J Pharm Pharmacol. 2015;67(10):1448-56.
  14. Szliszka E1, Zydowicz G, Mizgala E, Krol W. Artepillin C (3,5-dipresnyl-4-hydroxycinnamic acid) sensitizes LNCaP protate cancer cells to TRAIL-induced apoptosis. Int J Oncol. 2010 Sep;41(3):818-28.
  15. Shimizu K, Das SK, Hashimoto T, et al. Artepillin C in Brazilian propolis induces G(0)/G(1) arrest via stimulation of Cip1/p21 expression in human colon cancer cells. Mol Carcinog. 2005;44(4):293-9.
  16. Messerli SM, Ahn MR, Kunimasa K, et al. Artepillin C (ARC) in Brazilian green propolis selectively blocks oncogenic PAK1 signaling and suppresses the growth of NF tumors in mice. Phytother Res. 2009;23(3):423-7.
  17. Kuo YY, Jim WT, Su LC, et al. Caffeic Acid phenethyl ester is a potential therapeutic agent for oral cancer. Int J Mol Sci. 2015;16(5):10748-66.
  18. Rzepecka-stojko A, Kabała-dzik A, Moździerz A, et al. Caffeic Acid phenethyl ester and ethanol extract of propolis induce the complementary cytotoxic effect on triple-negative breast cancer cell lines. Molecules. 2015;20(5):9242-62.
  19. Motawi TK, Abdelazim SA, Darwish HA, Elbaz EM, Shouman SA. Could Caffeic Acid Phenethyl Ester Expand the Antitumor Effect of Tamoxifen in Breast Carcinoma?. Nutr Cancer. 2016;68(3):435-45.
  20. Liu CC, Hsu JM, Kuo LK, Chuu CP. Caffeic acid phenethyl ester as an adjuvant therapy for advanced prostate cancer. Med Hypotheses. 2013;80(5):617-9.
  21. Tazawa S, Arai Y, Hotta S, Mitsui T, Nozaki H, Ichihara K. Discovery of a Novel Diterpene in Brown Propolis from the State of Parana, Brazil. Nat Prod Commun. 2016;11(2):201-5.
  22. De mendonça IC, Porto IC, Do nascimento TG, et al. Brazilian red propolis: phytochemical screening, antioxidant activity and effect against cancer cells. BMC Complement Altern Med. 2015;15:357.
  23. Gao W, Wu J, Wei J, et al. Brazilian green propolis improves immune function in aged mice. J Clin Biochem Nutr. 2014;55(1):7-10.
  24. Shimizu T, Hino A, Tsutsumi A, Park YK, Watanabe W, Kurokawa M. Anti-influenza virus activity of propolis in vitro and its efficacy against influenza infection in mice. Antivir Chem Chemother. 2008;19(1):7-13.
  25. Franchin M, Cólon DF, Castanheira FV, et al. Vestitol Isolated from Brazilian Red Propolis Inhibits Neutrophils Migration in the Inflammatory Process: Elucidation of the Mechanism of Action. J Nat Prod. 2016;79(4):954-60.
  26. Bueno-silva B, Kawamoto D, Ando-suguimoto ES, Alencar SM, Rosalen PL, Mayer MP. Brazilian Red Propolis Attenuates Inflammatory Signaling Cascade in LPS-Activated Macrophages. PLoS ONE. 2015;10(12):e0144954.
  27. Anauate-netto C, Anido-anido A, Leegoy HR, et al. Randomized, double-blind, placebo-controlled clinical trial on the effects of propolis and chlorhexidine mouthrinses on gingivitis. Braz Dent Sci. 2014;17(1):11-15.
  28. Freires IA, Queiroz VCPP, Furletti VF, et al. Chemical composition and antifungal potential of Brazilian propolis against Candida spp. J Mycol Med. 2016;26(2):122-132.
  29. Das neves MV, Da silva TM, Lima Ede O, Da cunha EV, Oliveira Ede J. Isoflavone formononetin from red propolis acts as a fungicide against Candida sp. Braz J Microbiol. 2016;47(1):159-66.
  30. Pippi B, Lana AJ, Moraes RC, et al. In vitro evaluation of the acquisition of resistance, antifungal activity and synergism of Brazilian red propolis with antifungal drugs on Candida spp. J Appl Microbiol. 2015;118(4):839-50.
  31. Sartori G, Pesarico AP, Pinton S, et al. Protective effect of brown Brazilian propolis against acute vaginal lesions caused by herpes simplex virus type 2 in mice: involvement of antioxidant and anti-inflammatory mechanisms. Cell Biochem Funct. 2012;30(1):1-10.
  32. Pimenta HC, Violante IM, Musis CR, Borges ÁH, Aranha AM. In vitro effectiveness of Brazilian brown propolis against Enterococcus faecalis. Braz Oral Res. 2015;29
  33. Jacob A, Parolia A, Pau A, Davamani amalraj F. The effects of Malaysian propolis and Brazilian red propolis on connective tissue fibroblasts in the wound healing process. BMC Complement Altern Med. 2015;15:294.
  34. Lima cavendish R, De souza santos J, Belo neto R, et al. Antinociceptive and anti-inflammatory effects of Brazilian red propolis extract and formononetin in rodents. J Ethnopharmacol. 2015;173:127-33.